The Real Cost of Estradiol, by Delivery Method

$39.99 a month, and that is what your card is charged — no membership here.

$39.99 a month, and this page shows its own math — each tube is a 3-month supply billed at $119.97.

The one Evernow row where the fee includes a medicine. Its Terms: membership "include[s] optional, complimentary access to vaginal estradiol cream… for members on quarterly or annual plans", and the product page prints "Get FREE vaginal estrogen cream* (worth up to $480/year) with a multi-month membership *Must medically qualify and be on a 3-or-12-month plan". Advertised is the "Starts at $35/month" card on that same page, which is the annual block ÷ 12. Walk-away is the cheapest plan that actually carries the cream: $129 for three months, charged in one payment, which is $43 a month and $516 a year. There’s no month-to-month plan that includes it, and the block is non-refundable once you have seen a provider.

Advertised "From $54 per month", a published floor. Billed every 28 days, so $702 a year rather than $648.

$69.99 a month, flat across all five strengths from 0.25 mg to 1.25 mg — a real quote rather than a starting point.

$69.99 a month at every dose Alloy sells, with no membership and no step-up.

$74.99 a month, and the page says outright that it’s "Shipped and billed every 3 months" — one of only two hormone pages that admits the block.

Advertised "From $89 per month" — a published floor, not a quote: Winona sets the dose after an intake and prints no ladder. Nothing to prepay and no membership, so the same figure is what one cycle costs a patient who then stops. Billed every 28 days per Winona's FAQ, so a year is 13 charges of $89 — $1,157, not the $1,068 that "per month" implies.

Advertised "From $89 per month", a published floor. Billed every 28 days, so 13 charges a year rather than 12.

The same price schedule as the single-hormone cream, which is the useful fact here: Hello Alpha charges no more for the two-hormone preparation than for estradiol alone, at every one of its three supply lengths. Advertised under the same "As low as $44/mo *" badge, whose asterisk covers both products by name.

Advertised "As low as $44/mo *" in the hero. The asterisk, at the foot of the same page: "* When you buy 2 months of Estradiol or Estradiol+DHEA vaginal creams. Includes free shipping. Hello Alpha membership fees are separate." $44 is the two-month block ($89.99) divided out; one month alone is "$59.99 for 1-month supply" on the same page.

Advertised "From $149 per month" — a published floor, and the dearest thing Winona sells. It’s also the only delivery method Winona's own treatments page doesn’t label "Compounded" — body cream, vaginal cream and pills all carry that label and the patch carries only "Plant-derived". At 13 charges a year that’s $1,937, against $1,157 for the cream carrying the same hormone.

Advertised "$40/mo + membership" — a flat figure, and the cheapest estrogen Hone sells. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor.

Advertised "$58/mo + membership" — a flat figure. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor.

Advertised "$58/mo + membership" — a flat figure, and the same price as Hone's estradiol gel and estriol vaginal cream. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor.

Advertised "$65/mo + membership" — a flat figure, and a branded product rather than a compounded one. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor.

Advertised "$80/mo + membership" — a flat figure, and the dearest estrogen preparation Hone lists. Hone describes it as "a 50/50 or 80/20 compound of estradiol and estriol". Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor.