Cheapest board
The Real Cost of Estradiol, by Delivery Method
Estradiol is the one hormone every company on this site that sells hormones actually sells, which makes it the only place you can compare them on the same molecule. The spread is larger than anything on our GLP-1 boards: the cheapest route is under $45 a month and the dearest is over $200, for the same drug. Two things do most of that work. One seller charges nothing for care and another adds a mandatory $155 membership to every product, so a $40 cream and a $195 cream can be the same $40 cream. And the delivery method moves the price by more than the seller does — a patch costs roughly twice a pill at the same company. This board is not curated: it is a query over our provider reviews, so a company appears the moment its review does, and the rows it leaves out are named underneath with the reason.
Nothing on this board is pinned, sponsored, or lifted into position — every row is sorted by walk-away price alone, cheapest first.
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What gets on this board
Every priced row on a published review here whose compound names estradiol, in any delivery method — pill, patch, gel, spray, vaginal cream, body cream or vaginal insert. A company selling five appears five times, because they are five different products at five different prices. A membership that includes estradiol at no extra charge is on the board with the plan stated in the row label, because it is a real route to the molecule at a published price. It excludes any row naming only estriol, which is a different molecule; and any row whose molecule the company never states — a product sold as "estrogen" with nothing more said is not a quote for estradiol, and listing it as one would assert an identity the seller has not published.
What decides the order
Nothing on this board is pinned, sponsored, or lifted into position — every row is sorted by walk-away price alone, cheapest first.
Where two rows carry the same walk-away price, the cheaper year goes first and then the two are ordered alphabetically — so every position on this page is decided by the numbers, and never by which review happened to be written first.
What the spread looks like
$40/mo
Cheapest walk-away
$235/mo
Dearest walk-away
$195
Between the two
Estradiol, cheapest first
Sorted by walk-away price alone — what you actually pay if you stop after one cycle, not the multi-month prepay number a provider leads with. Every figure, date and source on a row is the company's own, carried unmodified from its review — click the company name to read the working behind its price.
| Provider | Advertised | Walk-away | True year |
|---|---|---|---|
AL Alloy — pill Advertised "Starting at $39.99" over "1-month supply", with "$49 one-time fee includes unlimited doctor messaging" and "Delivered to your door for free" beneath it. ⚠ The page says "1-month supply" and Alloy bills it in 90-day blocks — $119.97 per 90 days in its own products API — which the patch and vaginal cream pages disclose and this one does not. "Starting at" is a dose floor with a real ladder behind it: 0.5 mg and 1 mg are both $119.97 per 90 days, 2 mg is $124.97 and 1.5 mg is $150.00, so a reader can land at $39.99, $41.66 or $50.00 a month. ⚠ A banner on this page reads "Limited time! 25% off your first Estradiol Pill order. Use code: PILL25" — a first-order discount, not the ongoing rate, and not filed. Verified · source Visit Alloy | $39.99/mo | $39.99/mo | $479.88 $39.99 × 12 months |
AL Alloy — vaginal cream ⚠ CONVERTED BY ALLOY, NOT BY US, WHICH IS WHY THIS ROW IS THE HONEST ONE IN THE CATALOGUE. The page leads "$39.99" over "Per month" and then states "Each tube is a 3 month supply, billed at $119.97" — $119.97 ÷ 3 = $39.99 exactly, with the block named. It is the only hormone product Alloy prices the arithmetic for on the page itself. ⚠ The catalogue tile for the same product does the opposite, printing "$119.97 / 3-month supply", so which figure a reader meets depends on which Alloy page they land on. A single SKU, so this figure is a quote rather than a floor. Verified · source Visit Alloy | $39.99/mo | $39.99/mo | $479.88 $39.99 × 12 months |
EV Evernow — vaginal cream, included in a 3-month membership The one Evernow row where the fee includes a medicine. Its Terms: membership "include[s] optional, complimentary access to vaginal estradiol cream… for members on quarterly or annual plans", and the product page prints "Get FREE vaginal estrogen cream* (worth up to $480/year) with a multi-month membership *Must medically qualify and be on a 3-or-12-month plan". Advertised is the "Starts at $35/month" card on that same page, which is the annual block ÷ 12. Walk-away is the cheapest plan that actually carries the cream: $129 for three months, charged in one payment, which is $43 a month and $516 a year. There is no month-to-month plan that includes it, and the block is non-refundable once you have seen a provider. Verified · source Visit Evernow | $35.00/mo | $43.00/mo | $516.00 $43.00 × 12 months |
WI Winona — estrogen tablets Advertised "From $54 per month", a published floor. Billed every 28 days, so $702 a year rather than $648. Verified · source Visit Winona | $54.00/mo | $54.00/mo | $702.00 $54.00 × 13 four-week cycles |
AL Alloy — gel, Divigel Advertised "$69.99" over "1-month supply". ⚠ ONE OF ONLY TWO ROWS HERE THAT IS NOT A FLOOR: Alloy's products API prices this gel at $209.97 per 90 days at 0.25, 0.5, 0.75, 1 and 1.25 mg — five doses, one price — so $69.99 is what a customer pays whatever they are prescribed. The 90-day block is not disclosed on this page. A banner on it reads "Limited time! 25% off your first order of Evamist® or Estradiol Gel. Use code: HRT25", which is a first-order discount and is not filed. Verified · source Visit Alloy | $69.99/mo | $69.99/mo | $839.88 $69.99 × 12 months |
AL Alloy — spray, Evamist Advertised "$69.99" over "1-month". The second of the two rows that is a quote rather than a floor — Alloy's products API carries a single Evamist SKU at $209.97 per 90 days, which is $69.99 a month with no dose tiers behind it. Same $69.99 as the gel for a different delivery method, and the same undisclosed 90-day block. Covered by the same "25% off your first order" banner as the gel, which is not filed. Verified · source Visit Alloy | $69.99/mo | $69.99/mo | $839.88 $69.99 × 12 months |
AL Alloy — patch, transdermal Advertised "Starting at $74.99" over "1-month supply", and this is the one hormone page that states the billing term in the hero: "Shipped and billed every 3 months." $224.97 per 90 days in Alloy's products API, which is $74.99 a month exactly. ⚠ "Starting at" is a dose floor here: 0.05 mg and 0.1 mg are $224.97 per 90 days, 0.025 mg and 0.0375 mg are $239.97, and 0.075 mg is $249.97 — $74.99, $79.99 or $83.32 a month, with the lower doses costing more. No page publishes that ladder. Verified · source Visit Alloy | $74.99/mo | $74.99/mo | $899.88 $74.99 × 12 months |
WI Winona — estrogen body cream, + estriol Advertised "From $89 per month" — a published floor, not a quote: Winona sets the dose after an intake and prints no ladder. Nothing to prepay and no membership, so the same figure is what one cycle costs a patient who then stops. Billed every 28 days per Winona's FAQ, so a year is 13 charges of $89 — $1,157, not the $1,068 that "per month" implies. Verified · source Visit Winona | $89.00/mo | $89.00/mo | $1,157.00 $89.00 × 13 four-week cycles |
WI Winona — vaginal estrogen cream Advertised "From $89 per month", a published floor. Billed every 28 days, so 13 charges a year rather than 12. Verified · source Visit Winona | $89.00/mo | $89.00/mo | $1,157.00 $89.00 × 13 four-week cycles |
HA Hello Alpha — 0.01% + DHEA 0.75% vaginal cream The same price schedule as the single-hormone cream, which is the useful fact here: Hello Alpha charges no more for the two-hormone preparation than for estradiol alone, at every one of its three supply lengths. Advertised under the same "As low as $44/mo *" badge, whose asterisk covers both products by name. ⚠ THE ADVERTISED FIGURE CONTAINS NEITHER THE REAL DRUG PRICE NOR THE MEMBERSHIP. Hello Alpha's own sentence, in the same FAQ block as the price schedule: "The cost of prescription products are in addition to the monthly cost for your Hello Alpha membership." Its menopause page's step 1 is "Create an account online and choose Alpha Plus+ membership", priced on /membership at "$2.63 /day $79 per month". So the walk-away figure is $59.99 for one month of cream plus $79 of membership — $138.99. ⚠ Hello Alpha's own membership page also lists Menopause under its $29 Basic plan, which would make the same cream $88.99; the two pages are not reconciled anywhere, and the dearer route — the one the menopause page itself instructs — is the one filed. A fixed strength, so this figure is a quote rather than a floor. Verified · source Visit Hello Alpha | $44.00/mo | $138.99/mo | $1,667.88 $138.99 × 12 months |
HA Hello Alpha — 0.1% vaginal cream Advertised "As low as $44/mo *" in the hero. The asterisk, at the foot of the same page: "* When you buy 2 months of Estradiol or Estradiol+DHEA vaginal creams. Includes free shipping. Hello Alpha membership fees are separate." $44 is the two-month block ($89.99) divided out; one month alone is "$59.99 for 1-month supply" on the same page. ⚠ THE ADVERTISED FIGURE CONTAINS NEITHER THE REAL DRUG PRICE NOR THE MEMBERSHIP. Hello Alpha's own sentence, in the same FAQ block as the price schedule: "The cost of prescription products are in addition to the monthly cost for your Hello Alpha membership." Its menopause page's step 1 is "Create an account online and choose Alpha Plus+ membership", priced on /membership at "$2.63 /day $79 per month". So the walk-away figure is $59.99 for one month of cream plus $79 of membership — $138.99. ⚠ Hello Alpha's own membership page also lists Menopause under its $29 Basic plan, which would make the same cream $88.99; the two pages are not reconciled anywhere, and the dearer route — the one the menopause page itself instructs — is the one filed. ⚠ A quote rather than a floor: Hello Alpha sells one strength of this cream and prices it by supply length, not by dose — $59.99 for one month, $89.99 for two, $139.99 for "3-months supply + Get 1 month free for a total 4-months supply", which works out at $35.00 a month and is cheaper than the badge Hello Alpha chose to advertise. Verified · source Visit Hello Alpha | $44.00/mo | $138.99/mo | $1,667.88 $138.99 × 12 months |
WI Winona — estrogen patch, transdermal Advertised "From $149 per month" — a published floor, and the dearest thing Winona sells. It is also the only delivery method Winona's own treatments page does not label "Compounded" — body cream, vaginal cream and pills all carry that label and the patch carries only "Plant-derived". At 13 charges a year that is $1,937, against $1,157 for the cream carrying the same hormone. Verified · source Visit Winona | $149.00/mo | $149.00/mo | $1,937.00 $149.00 × 13 four-week cycles |
HH Hone Health — vaginal cream, Estrace Advertised "$40/mo + membership" — a flat figure, and the cheapest estrogen Hone sells. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor. Verified · source Visit Hone Health | $40.00/mo | $195.00/mo | $2,340.00 $195.00 × 12 months |
HH Hone Health — gel Advertised "$58/mo + membership" — a flat figure. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor. Verified · source Visit Hone Health | $58.00/mo | $213.00/mo | $2,556.00 $213.00 × 12 months |
HH Hone Health — patch Advertised "$58/mo + membership" — a flat figure, and the same price as Hone's estradiol gel and estriol vaginal cream. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor. Verified · source Visit Hone Health | $58.00/mo | $213.00/mo | $2,556.00 $213.00 × 12 months |
HH Hone Health — vagifem, vaginal inserts Advertised "$65/mo + membership" — a flat figure, and a branded product rather than a compounded one. Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor. Verified · source Visit Hone Health | $65.00/mo | $220.00/mo | $2,640.00 $220.00 × 12 months |
HH Hone Health — bi-est cream, and estriol Advertised "$80/mo + membership" — a flat figure, and the dearest estrogen preparation Hone lists. Hone describes it as "a 50/50 or 80/20 compound of estradiol and estriol". Walk-away is the drug price Hone prints plus the $155/month Premium membership its own product pages require ("Premium Tier" badge; Basic at $25 reaches only "Treatments labeled BASIC"). The membership is charged once per patient, not once per product, so a reader on two of these pays it once. Billed monthly — 12 charges — but Hone says some prescriptions ship as a 28-day supply on a cycle "not linked" to billing, so the annual figure is a floor. Verified · source Visit Hone Health | $80.00/mo | $235.00/mo | $2,820.00 $235.00 × 12 months |
17 published estradiol prices, from $40 to $235
One mark per row above, at the walk-away price for a single cycle — the standing rate with no commitment. Marks that would overlap stack upward; none is moved sideways. The dashed line is the middle row, $89, a real published price rather than an average of two.
Cheapest
$40
Middle row
$89
Dearest
$235
- Alloy — pill: $40 per cycle
- Alloy — vaginal cream: $40 per cycle
- Evernow — vaginal cream, included in a 3-month membership: $43 per cycle
- Winona — estrogen tablets: $54 per cycle
- Alloy — gel, Divigel: $70 per cycle
- Alloy — spray, Evamist: $70 per cycle
- Alloy — patch, transdermal: $75 per cycle
- Winona — estrogen body cream, + estriol: $89 per cycle
- Winona — vaginal estrogen cream: $89 per cycle
- Hello Alpha — 0.01% + DHEA 0.75% vaginal cream: $139 per cycle
- Hello Alpha — 0.1% vaginal cream: $139 per cycle
- Winona — estrogen patch, transdermal: $149 per cycle
- Hone Health — vaginal cream, Estrace: $195 per cycle
- Hone Health — gel: $213 per cycle
- Hone Health — patch: $213 per cycle
- Hone Health — vagifem, vaginal inserts: $220 per cycle
- Hone Health — bi-est cream, and estriol: $235 per cycle
True year assumes 13 payments a year for providers billing every 4 weeks, and 12 for providers billing monthly — see the arithmetic under each row.
What is not on this board, and why
A board that only shows what it includes is a board you have to trust. These are the priced rows we hold that look like they belong here and do not, each with the reason and a link to the review that prices it. The list is checked against the reviews on every build: a row that is neither on the board above nor named here fails the build rather than disappearing quietly.
Show all 8 excluded rows
Joi + Blokes — Systemic estrogen — capsule, molecule unnamed
Joi + Blokes never names the molecule in these products — its own pages say only "systemic estrogen" or "vaginal estrogen". Ranking them as estradiol would assert an identity the company does not publish, and guessing is how a cheapest board goes wrong. Its progesterone and testosterone rows, which it does name, are priced on its review.
Joi + Blokes — Systemic estrogen — cream, molecule unnamed
Joi + Blokes never names the molecule in these products — its own pages say only "systemic estrogen" or "vaginal estrogen". Ranking them as estradiol would assert an identity the company does not publish, and guessing is how a cheapest board goes wrong. Its progesterone and testosterone rows, which it does name, are priced on its review.
Joi + Blokes — Vaginal estrogen — cream, molecule unnamed
Joi + Blokes never names the molecule in these products — its own pages say only "systemic estrogen" or "vaginal estrogen". Ranking them as estradiol would assert an identity the company does not publish, and guessing is how a cheapest board goes wrong. Its progesterone and testosterone rows, which it does name, are priced on its review.
Joi + Blokes — Systemic estrogen — patch, molecule unnamed
Joi + Blokes never names the molecule in these products — its own pages say only "systemic estrogen" or "vaginal estrogen". Ranking them as estradiol would assert an identity the company does not publish, and guessing is how a cheapest board goes wrong. Its progesterone and testosterone rows, which it does name, are priced on its review.
Joi + Blokes — Vaginal estrogen — suppository, molecule unnamed
Joi + Blokes never names the molecule in these products — its own pages say only "systemic estrogen" or "vaginal estrogen". Ranking them as estradiol would assert an identity the company does not publish, and guessing is how a cheapest board goes wrong. Its progesterone and testosterone rows, which it does name, are priced on its review.
Winona — Estrogen + progesterone body cream — compounded
Winona names the molecule on its single-hormone creams — "compounded estradiol" — and does not name it on this combined preparation, which it sells only as "Estrogen + progesterone". Its estrogen is very likely the same one, and "very likely" is not a basis for putting a figure in a column headed estradiol. The price is on the Winona review with the same two columns, and it is ranked on our HRT board.
Winona — Estriol face cream with tretinoin — sold only as a 3-month supply
Estriol rather than estradiol, and sold for the skin rather than as hormone therapy — Winona describes it as "a powerful formula tailored for menopausal skin". It fails this board's rule twice over, and it is caught here only because the candidate net deliberately takes the whole estrogen family so that nothing falls between the boards unnoticed.
Hone Health — Estriol vaginal cream
Estriol, a different molecule, and Hone prices it separately from the estradiol vaginal cream on the same page — $50 a month against $40 — so the two are not interchangeable even at this one seller. Its price is on the Hone Health review and it is ranked on our HRT board.
Key terms
- Walk-away price
- What one cycle costs at the no-commitment, ongoing rate — what you actually pay if you stop after month one.
- True year
- The walk-away price multiplied by however many times a year it's actually billed — 12 for a calendar-month cycle, 13 for a four-week cycle.
- Plan price
- One price covering either of two molecules, quoted by the plan rather than the drug. Rows like that say so in the label, because the company publishes no figure for this compound on its own.
Frequently asked questions
Is this every company selling estradiol?
No, and the page does not claim it. It is every company whose estradiol price we have read off its own product page and published a review of — and, structurally, all of them: the board is generated from the review registry rather than kept as a second list beside it, so a company cannot be researched, reviewed and then forgotten here. What it is not is a census of the market. Every row we deliberately leave off is named further down this page with the reason.
Why is the same drug $40 at one seller and $195 at another?
Mostly because of what else is in the price, and the gap is bigger than the drug. One seller on this board charges $155 a month for a membership that every hormone product on its site requires, so its $40 estradiol cream is a $195 charge — the membership is nearly four times the medicine. Another charges nothing at all for care and bills only the drug. A third charges $79 a month for membership on top of a $59.99 cream. The walk-away column adds each of those in, which is the only way two sellers can be compared at all; the drug prices underneath them are much closer together than the totals suggest.
Why does the delivery method change the price so much?
That is the second finding on this board and we can only report it, not explain it — none of these sellers explains it either. At one company an estradiol pill is $39.99 a month and a patch carrying the same hormone is $74.99. At another the vaginal cream is $40 and the patch is $58 before membership. At a third the tablet is $54 a cycle and the patch is $149. The pattern holds across sellers with no exception on this board, and no product page anywhere gives a reason for it. What this site will not do is tell you which method to choose — that is a clinical question and this is a pricing page.
Why does the true-year column not simply multiply by twelve?
Because it multiplies by however many times a company actually bills, and on this board one seller genuinely differs. Winona's own FAQ says "Payment and prescription for a 30-day supply are automatically processed every 28 days" — thirteen charges a year rather than twelve — so its $89 cream is $1,157 a year and not $1,068. Nothing on Winona's site shows you that figure. The multiplier is printed under every row and is copied from each company's review rather than assumed. Separately, several sellers here bill in 90-day blocks and show a per-month figure: that divides cleanly and does not change the annual total, but it does mean the smallest sum you can actually commit is three months.
Some rows say "estradiol and estriol". Are those really estradiol prices?
They are prices for a preparation containing estradiol, and the row label says what else is in it. Two sellers here compound the two estrogens together — one calls it a body cream, the other a bi-est cream — and a reader pricing estradiol who never saw them would be missing a real route to it at a published price. What is off the board is the reverse case: a preparation containing only estriol, which is a different molecule and is named in the exclusions below.
Why are some hormone prices missing from this board but on your HRT board?
Because the seller never says what is in them. At least one company on our HRT board sells products called simply "Systemic Estrogen" and "Vaginal Estrogen" and states nowhere whether that is estradiol, estriol or a conjugated preparation. Those prices are real and they are ranked on the HRT board, where the question is what a hormone product costs. They are not here, because a column headed estradiol makes a claim about every figure in it, and we are not going to make that claim on a seller's behalf. It is the same rule that keeps compounded GLP-1s of unnamed molecule off our semaglutide and tirzepatide boards.
How current are these prices?
Every figure was read off the company's own product page on the date printed beside it, and each row links to the review that shows the working. Prices in this category move, and the way they are presented moves too — on the day we checked, one seller's product page and its own catalogue tile gave the same cream as "$39.99 per month" and "$119.97" respectively, and both were correct about different things. Read the number on your own checkout screen, not the one on the page that sent you there; if a source disagrees with this page, the source is right and we want to know.
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.