Enhance.MD Review: The $212 Headline Is a 48-Week Prepay

$249 every four weeks for compounded semaglutide, $329 for compounded tirzepatide, and $379 for GLP-1 Elite, which is both molecules together. The $212, $280 and $322 the site leads with are the same plans bought as 48-week blocks — one payment of $2,544, $3,360 or $3,864 — presented as a monthly rate. Enhance.MD's own catalog says so in the plan breakdown it shows inside the app: "$2,544 charged every 48 weeks. Equivalent to paying $212/mo." Read on August 9, 2026 from both the product pages and the pricing endpoint the sign-up app calls.

From subtracting a one-time coupon from a number that was never a monthly charge. $112 is $212 minus $100, and the $100 is SUMMER100, which Enhance.MD's own intake banner describes as "Applied to your first order only." The order it applies to is the single $2,544 payment for 48 weeks, so what you would actually be charged on day one is $2,444. The same construction produces "$180 first month" for tirzepatide and "$222 first month" for Elite. If you want a genuinely small first payment, the code that does that’s SUMMER50, which takes $50 off the month-to-month plan and makes the first four weeks $199 before it reverts to $249.

Because Enhance.MD doesn’t bill by the calendar. Its FAQ says the membership "will automatically renew every 28 days", and the plans are counted in weeks throughout — the "3 month plan" bills every 12 weeks, the "6 month plan" every 24, and the "12 month plan" every 48. Forty-eight weeks isn’t a year. So there are thirteen four-week cycles in every twelve months at any plan length: semaglutide month-to-month is $3,237 a year rather than $2,988, and even the 48-week block works out at $2,756 a year rather than the $2,544 its own total suggests.

No, and this is the part Enhance.MD does well. The FAQ answers it directly: "The costs of our programs include lab work, virtual medical provider visits, medication through partnered pharmacies, and shipping… there are no hidden fees." The shipping policy backs the last of those — "We provide 2-day priority on all shipments, which is included within the Enhance.MD pricing shown" — and the plan features list the provider evaluation, lab screenings every six months and one-on-one nutrition and fitness coaching inside the same price. The naming is the only confusing part: the four-week SKUs are called "membership" and "membership-1" in the company's own catalog, which sounds like a second charge and isn’t one.

No. "Same Pricing — All Doses" appears on every product page, and the pricing data behind the app agrees: each plan is one number keyed to the plan length, with no dose term anywhere in it. Semaglutide is $249 a cycle across the whole 0.25 mg to 2.5 mg range and tirzepatide is $329 across 2.5 mg to 15 mg. On drugs you’re expected to titrate upward over months, that turns a quote into a plan — a price taken at a starting dose elsewhere in this category often tells you very little about what month six costs.

Forty of them, and its own two answers to this question don’t match, so use the stricter one. The gate inside the sign-up app admits 38 states served by Enhance Wellness PC plus Arizona and California, which route to a second medical group, iThriveMD PC, and it explicitly refuses Alabama, Arkansas, Georgia and South Carolina. That leaves Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, South Carolina, Tennessee and West Virginia with no route through the intake. Enhance.MD's FAQ publishes a different list that includes Washington, D.C. and West Virginia and leaves out North Dakota. The gate is the one that decides whether your address is accepted, so if you’re in DC or West Virginia, expect the intake to stop you regardless of what the FAQ says.

It’s semaglutide and tirzepatide prescribed together — both molecules, not a choice between them — and Enhance.MD positions it for people who have plateaued on a single agonist. At $379 every four weeks it’s $50 more than tirzepatide alone and $199 less than paying for Core and Advanced separately, which would be $578 a cycle. Whether it’s worth the premium is a clinical question rather than a pricing one, and the honest answer is that combination compounded GLP-1 therapy has no outcome data behind it of the kind that supports either drug on its own. The arithmetic is at least clean: $4,927 a year at thirteen charges, or $4,186 if you commit $3,864 up front for 48 weeks.

Because Enhance.MD doesn’t sell one. Microdosed tirzepatide has exactly three plans — 12 weeks at $567, 24 weeks at $1,074 and 48 weeks at $2,028 — so the smallest commitment is $567, or $189 per four-week cycle. It exists as a landing place rather than a product you pick: the BMI calculator in the intake offers it to people who don’t meet the criteria for standard-dose treatment, with the line "You may be eligible for GLP-1 Microdosing Tirzepatide. Would you like to explore this option instead?" One warning about the number. The $169 headline on that page is also, coincidentally, the monthly price of Enhance.MD's NAD+ injection, which is advertised on the same page in the comparison card immediately beneath the plans. They are different products that happen to cost the same.

No. Screened on August 9, 2026 against FDA's live warning-letter index. A full-text search for "enhance md" returns 28 letters and not one of them names Enhance in the company column — they’re device, food and clinical-investigator letters that happen to contain the words. The condensed forms "enhancemd" and "enhance.md" return nothing, and neither do the two medical groups, Enhance Wellness PC and iThriveMD PC. The three pharmacies named in the Terms — Rite-Away, Vios Compounding and TruMedsRx — were screened separately and none holds a letter against itself. Worth saying plainly what that does and doesn’t mean: no letter isn’t a clean bill of health, only an absence of one particular public regulatory communication.

Only in one narrow window, and it closes early. Enhance.MD takes payment at the end of the intake, before the video visit — its own getting-started sequence is intake, payment, then "a virtual meeting with a healthcare provider" — and the only refund it commits to is for people it turns down: "If you are not deemed a candidate for the Enhance.MD program, you will be issued a refund." After that, the acknowledgment you have to tick to place the order says "completed prescription orders cannot be canceled, refunded, or returned", and the shipping policy repeats that prescription products can’t be returned under any circumstances. Canceling stops the next renewal rather than recovering the last one, and you do it by emailing support@enhance.md or calling 888-299-5088 — there’s no cancel button described anywhere on the site.